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Showing 1 to 12 of 230 entries
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Cytoprotective effect of Semecarpus anacardium against toxicity induced by Streptozotocin in rats.

Journal of experimental pharmacology

Aseervatham J, Palanivelu S, Sachdanandam P.
PMID: 27186099
J Exp Pharmacol. 2010 Aug 25;2:135-43. doi: 10.2147/JEP.S11466. eCollection 2010.

Leakage of cellular enzymes into the plasma is a clear indication of cell damage. When liver plasma membrane is damaged, a variety of enzymes normally located in the cytosol are released into the blood stream and their estimation is...

Effects of single-dose morning and evening administration of pravastatin on antioxidant markers in cholesterol-fed rabbits.

Journal of experimental pharmacology

Kamal SM.
PMID: 27186110
J Exp Pharmacol. 2011 May 12;3:51-8. doi: 10.2147/JEP.S19449. eCollection 2011.

BACKGROUND: Accurate timing of statin administration is considered important to obtain the best hypolipidemic effect. Pravastatin is one of the currently prescribed hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, and was chosen in this study to evaluate its antioxidant effect...

Hibiscus sabdariffa L., roselle calyx, from ethnobotany to pharmacology.

Journal of experimental pharmacology

Carvajal-Zarrabal O, Barradas-Dermitz DM, Orta-Flores Z, Hayward-Jones PM, Nolasco-Hipólito C, Aguilar-Uscanga MG, Miranda-Medina A, Bujang KB.
PMID: 27186114
J Exp Pharmacol. 2012 Feb 28;4:25-39. doi: 10.2147/JEP.S27974. eCollection 2012.

Using MEDLINE and SCOPUS databases, a review of the literature from the pioneering study of 1991 until 2010 was performed on the effects on biological models of Hibiscus sabdariffa L. roselle calyx, its extracts mainly in polar solvents, or...

Progress toward therapeutic potential for AFQ056 in Fragile X syndrome.

Journal of experimental pharmacology

Sourial M, Cheng C, Doering LC.
PMID: 27186135
J Exp Pharmacol. 2013 Jul 16;5:45-54. doi: 10.2147/JEP.S27044. eCollection 2013.

Fragile X syndrome (FXS) is the most common form of inherited intellectual disability and the leading single-gene cause of autism. It is caused by the lack of production of the Fragile X mental retardation protein (FMRP), resulting in cognitive...

Effect of combined therapy of diabinese and nicotinic acid on liver enzymes in rabbits with dithizone-induced diabetes.

Journal of experimental pharmacology

Monago CC, Onwuka F, Osaro E.
PMID: 27186100
J Exp Pharmacol. 2010 Oct 07;2:145-53. doi: 10.2147/JEP.S11490. eCollection 2010.

The effects of diabinese, a known antidiabetic drug, and the combined effects of diabinese and nicotinic acid, a vitamin and antilipidemic drug, were studied in rabbits with dithizone-induced diabetes. Side effects of diabinese include hypoglycemia and liver toxicity. Dithizone...

Investigational new drugs in the treatment of inflammatory bowel disease: a review.

Journal of experimental pharmacology

Williams I, Goh J.
PMID: 27186106
J Exp Pharmacol. 2011 Feb 25;3:13-9. doi: 10.2147/JEP.S7806. eCollection 2011.

The unraveling of the immuno-pathobiology of inflammatory bowel disease (IBD) in the past three decades has ushered in a new era of translational medicine. The biotechnology revolution has resulted in a paradigm shift in how clinicians view and treat...

Chronic khat (.

Journal of experimental pharmacology

Alele PE, Ajayi AM, Imanirampa L.
PMID: 24348075
J Exp Pharmacol. 2013 Jun 24;2013(5). doi: 10.2147/JEP.S46635.

INTRODUCTION: Khat (METHODS: Adult male Sprague-Dawley rats were randomly assigned to one of six dose groups: 2 g/kg khat; 4 g/kg khat; 4 g/kg ethanol; combined khat and ethanol (4 g/kg each); control; and an untreated group. Treatments were...

The warfarin-cranberry juice interaction revisited: A systematic in vitro-in vivo evaluation.

Journal of experimental pharmacology

Ngo N, Brantley SJ, Carrizosa DR, Kashuba AD, Dees EC, Kroll DJ, Oberlies NH, Paine MF.
PMID: 20865058
J Exp Pharmacol. 2010 Jul;2010(2):83-91. doi: 10.2147/JEP.S11719.

BACKGROUND: Cranberry products have been implicated in several case reports to enhance the anticoagulant effect of warfarin. The mechanism could involve inhibition of the hepatic CYP2C9-mediated metabolic clearance of warfarin by components in cranberry. Because dietary/natural substances vary substantially...

A(2A) adenosine receptor-mediated increase in coronary flow in hyperlipidemic APOE-knockout mice.

Journal of experimental pharmacology

Teng B, Mustafa SJ.
PMID: 21847356
J Exp Pharmacol. 2011 Jul;2011(3):59-68. doi: 10.2147/JEP.S18945.

Adenosine-induced coronary vasodilation is predominantly A(2A) adenosine receptor (AR)-mediated, whereas A(1) AR is known to negatively modulate the coronary flow (CF). However, the coronary responses to adenosine in hyperlipidemia and atherosclerosis are not well understood. Using hyperlipidemic/atherosclerotic apolipoprotein E...

Enhanced efficacy of chemically modified curcumin in experimental periodontitis: systemic implications.

Journal of experimental pharmacology

Wang HH, Lee HM, Raja V, Hou W, Iacono VJ, Scaduto J, Johnson F, Golub LM, Gu Y.
PMID: 30774454
J Exp Pharmacol. 2019 Jan 23;11:1-14. doi: 10.2147/JEP.S171119. eCollection 2019.

INTRODUCTION: Dental microbial biofilm initiates gingival inflammation, and its suppression is the current dominant strategy for treating periodontitis. However, the host response to the biofilm is largely responsible for the connective tissue breakdown including alveolar bone loss, which is...

Evaluation of in vitro and in vivo Anti-Diabetic, Anti-Hyperlipidemic and Anti-Oxidant Activity of Flower Crude Extract and Solvent Fractions of .

Journal of experimental pharmacology

Kifle ZD, Yesuf JS, Atnafie SA.
PMID: 32607006
J Exp Pharmacol. 2020 Jun 09;12:151-167. doi: 10.2147/JEP.S249964. eCollection 2020.

BACKGROUND: The flower of METHODS: The in vitro α-amylase inhibition and antioxidant activity of the crude extract and solvent fractions of RESULTS: The acute toxicity study of CONCLUSION: The result demonstrated the beneficial biochemical effects of

Therapeutic Effects of .

Journal of experimental pharmacology

Moradi-Kor N, Ghanbari A, Rashidipour H, Bandegi AR, Yousefi B, Barati M, Kokhaei P, Rashidy-Pour A.
PMID: 32256126
J Exp Pharmacol. 2020 Mar 19;12:75-85. doi: 10.2147/JEP.S237378. eCollection 2020.

OBJECTIVE: The amygdala structural and functional abnormalities have been implicated in numerous neuropsychiatric and neurodevelopmental disorders. Given the important role of the amygdala in stress responses and the susceptibility of the females to adolescent stress, the present study investigated...

Showing 1 to 12 of 230 entries